Aims: Gastric metastases are a rare event in the natural history of breast cancer.
Report of the Case: We report the case of a gastric metastasis occurred 14 years after initial treatment for breast carcinoma.
Discussion: Gastric metastases don’t exceed 0,3% of all metastases. Diagnosis is based on pathological examination of biopsies or surgical specimens. It is difficult to prove their primitive or secondary origin. Treatment consists on chemotherapy and or hormonal therapy.
Conclusion: The prognosis is similar to those with metastatic disease.
Aim: To describe an unusual case of colorectal cancer with metastases to various extra-abdominal sites, including subcutaneous tissues as an extremely rare clinical event with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) findings.
Presentation of Case: We report a case of 51-year-old female patient with metastases of BRAF V600E mutant colorectal adenocarcinoma to the subcutaneous tissue, left kidney, left breast, lower back, anterior abdominal wall, and gluteal region, which was detected by whole body 18F-FDG-PET/CT. Histopathological examination of excisional specimen of a lumbar subcutaneous nodular mass revealed an adenocarcinoma metastasis with RAS wild type, BRAF V600E mutation. The patient was treated with 12 cycles of FOLFOXIRI combined with bevacizumab regimen for 6 months. Follow-up 18F-FDG-PET/CT after the end of therapy revealed complete metabolic response.
Discussion: Subcutaneous metastasis of colorectal cancer with BRAF V600E mutation is a rare but important phenomenon and has poor prognosis. Triplet chemotherapy plus bevacizumab is the treatment of choice due to its aggressive type of tumor. 18F-FDG-PET/CT is a very effective imaging modality to demonstrate all malignant masses before treatment and to evaluate treatment response.
Conclusion: It is essential to be familiar with the rare association of colorectal cancer and breast, kidney, muscle, and subcutaneous metastases to improve diagnostic accuracy and patient management. 18F-FDG-PET/CT imaging is very effective to demonstrate all malignant masses before treatment and to exclude the coexistence of another possible primary tumors via treatment results.
Background: Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer mortality after lung cancer worldwide. The incidence of this disease is high among men of African descent. The modes of presentation of patients with prostate cancer are varied. In this paper, we present an overview of the modes of clinical presentation of men with suspected prostate cancer and their relationship with the histological diagnosis of prostate cancer.
Materials and Methods: This was a prospective and hospital‑based study. Patients who had a prostate biopsy done due to elevated serum prostate‑specific antigen (PSA) levels, abnormal digital rectal examination (DRE) findings of the prostate gland, or a combination of both were included in this study. Their biodata, modes of presentation, and other clinical and histological information were recorded in a pro forma. Data analysis was done using the statistical programming for social sciences (SPSS) version 21. For all statistical tests, P < 0.05 was regarded as significant.
Results: One hundred and thirty-two patients were recruited into this study. The mean age of the patients was 69.75 ± 9.15 years. Most participants (75%) were in their seventh and eighth decades of life. The mean serum PSA level was 35.01±8.52ng/ml (range: 6 to 164ng/ml), while the mean prostate volume was 101.4 ± 91.4 ml (range: 10–635ml).
Lower urinary tract symptoms (LUTS) were the most common mode of presentation accounting for 97.7% (n=129) of the cases studied. This was followed by haematuria (34.1%, n=45), low back pain (25.8%, n=34), weight loss (22.7%, n=30), and paraplegia/paraparesis (7.6%, n=10). Bone pains and paraparesis/paraplegia significantly correlated with the diagnosis of adenocarcinoma of the prostate.
Conclusion: The majority of men with suspected prostate cancer were found to be symptomatic at presentation. The modes of presentation were varied with LUTS being the most common. Low back pain and paraparesis/paraplegia were positive predictors of prostate cancer disease.
With the application of nanomedicine for herbal medicines, it can be developed into nano herbal meditation with high bioavailability characteristics and provide a pathway of new research in herbal drug delivery mechanisms. But the major challenge was its low absorption because of the cell's lipid membrane, high molecular size resulting in loss of bioavailability and efficiency. Nanotechnology proactively is able to extract the ingredients of the herbal medicinal plants reducing their side effects and improving their activities. The motive of the research is to comprehensively explore the understanding regarding herbal nanotechnology and analyze the potential advantages of herbal nanotechnology in retardation of cancer cells. For this perspective the paper selects a secondary methodology which exclusively analyses the 33 studies and tries to determine the research objective and the paper also emphasises on the future perspective of herbal nanotechnology.
Non small cells carcinoma represents the most frequent histological subtype in lung cancers.
We report, through a review of literature, the indications of radiotherapy in patients presenting with non metastatic lung non small cell carcinoma.
Postoperative radiotherapy seemed to improve local control, without any benefit on overall survival. Therapeutic indications for N2 stage are still controversial. Concomitant radiotherapy and chemotherapy is the standard of care in non operable non small cell lung cancer. Chemotherapy protocols should include platinium. Stereotaxic radiotherapy is indicated for patients with non operable small tumors.
Improvement in delivering systems in radiotherapy improves the treatment results in non small cell lung cancers.
Radiotherapy has an important role in the treatment of this entity. Conformal radiotherapy tested dose escalation with improvement in local control and preserved organs at risk.