Asian Oncology Research Journal 2021-06-07T13:49:18+00:00 Asian Oncology Research Journal Open Journal Systems <p style="text-align: justify;"><strong>Asian Oncology Research Journal</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AORJ/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cancer, Tumor&nbsp;and&nbsp;Oncology&nbsp;research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> Melanoma of Inguinal Region with Metachronous Primary Squamous Cell Carcinoma of Laryngopharynx: A Rare Case Report 2021-03-31T09:35:31+00:00 Tazyeen Fatima <p>Presence of multiple primary cancers in a single patient with different histopathological entities is an rare occurrence. Here we are reporting a case of 80 year old male diagnosed as malignant melanoma with metachronous primary squamous cell carcinoma of laryngopharynx<strong>.</strong></p> 2021-03-31T00:00:00+00:00 ##submission.copyrightStatement## Versatile, Bi-paddle Pectoralis Major Myocutaneous Flap in a High Risk Geriatric Male with Multiple Co-Morbidities, Presented with Advanced, Complex Oro-mandibular Cancer: A Case Report 2021-06-07T13:49:18+00:00 Sachin S. Kadam Tejaswini Kadam <p>The study reporting a case of a 78 year old elderly male patient with multiple co-morbidities&nbsp; with poor performance status with advanced oro-mandibular cancer who underwent oncological resection followed by reconstruction with bi-paddle PMMC flap as an alternative to micro-vascular free flap. Composite resection of the advanced or-mandibular cancer results in extensive defects which poses a challenge to the treating team as it will be difficult to restore mastication, speech and swallowing function. In head and neck cancers, free flaps have been used increasingly to cover the defect with the help of experienced and trained surgeons with fine skills of micro-vascular procedures. However , free flaps are not easily available at all centers in developing countries because of resource constraint, cost and expertise of surgeon. PMMC flap is the robust flap and it has been described and established since long in covering the both, intra and extra oral defects . With the help of random flap and multiple perforators, PMMC flap can mould into bi-lobed / bi-paddle / folded version which can cover intra-oral defect with covering of external lining. Bi-paddle PMMC flap is highly vascularized, versatile flap with short and easy learning curve and produces satisfactory aesthetic and functional results and should be considered as a first option in a geriatric patient with multiple co-morbidities.</p> 2021-06-07T00:00:00+00:00 ##submission.copyrightStatement## The Protective Effect of 9-Diaminoacridine against Ehrlich Ascites Carcinoma (EAC) Induced Spleen Injury in Female Mice 2021-04-07T10:59:20+00:00 Ehab Tousson Afaf El-Atrash Ibrahim El Tantawy El Sayed Ezar Hafez Hebat Allah El Basyouny Ramadan M. Kandyel <p><strong>Background and Objective:</strong> The study aims to evaluate the protective activity of 9-Diaminoacridine (N1-(acridin-9-yl) propane-1, 3-diamine hydrochloride; 9-DAAD) against Ehrlich Ascites Carcinoma (EAC) bearing mice.</p> <p><strong>Materials and Methods:</strong> A total forty mice were randomly divided into four groups (1<sup>st</sup> group, control mice were injected with 0.1% DMSO 15 ml/ Kg bw subcutaneously; 2<sup>nd</sup> group, mice were administered with 9-DAAD (30 mmol/ kg bw every 3 day) subcutaneously for 2 weeks; 3<sup>rd</sup> group, mice were injected interaperitonealy with 2.5×10<sup>6</sup> EAC cells/mouse; 4<sup>th</sup> group, were injected with EAC as the 3<sup>rd</sup> group then administered with 9-DAAD for another 2 weeks).</p> <p><strong>Results:</strong> The results showed that; EAC exhibit a significant reduction in RBCs, Hb, HCT, MCV, MCH, MCHC levels. Moreover, EAC exhibit a significant elevation in WBCs and PLT levels when compared to the control group.</p> <p>Many histopathological alterations were observed within the splenic tissue of the EAC group as cellular degeneration of red and white pulps, several necrotic cells, vacuolar degeneration, and notable amyloid deposition. In addition, there is a significant increase in the activity of caspase-3 and vascular endothelial growth factor (VEGF) expressions. On the other hand; treatment of EAC mice with 9-DAAD regularized serum levels of the above-mentioned parameters and also restore the splenic tissue normal histological architecture.</p> <p><strong>Conclusion:</strong> The results indicated that the 9-DAAD possesses a protective activity against EAC induced changes in blood, biochemical parameters and splenic injury. Further studies are warranted to explore its mode of action and safety for medicinal use in cancer therapy.</p> 2021-03-31T00:00:00+00:00 ##submission.copyrightStatement##