Asian Oncology Research Journal

Unveiling the Crises of Breast Cancer in Young Nigerian Women: A Ten Year Retropsective Study in a North Central State

Philip Ojile Akpa *

Department of Pathology, University of Jos, Jos, Plateau State, Nigeria and Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Innocent Emmanuel

Department of Pathology, University of Jos, Jos, Plateau State, Nigeria and Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Barka Vandi Kwaghe

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Samuel Abinu Abaniwo

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Ishaku Agahu Othman

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

James Eveshojiame Ben

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Nanisi Zorto Bahaushe

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Jacob Anzaku Emmanuel

Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Olugbenga Akindele Silas

Department of Pathology, University of Jos, Jos, Plateau State, Nigeria and Department of Anatomic Pathology and Forensic Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

*Author to whom correspondence should be addressed.

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Abstract

Aims: To determine the proportion of breast cancers that occur in young women at the Jos University Teaching Hospital, Jos, Plateau State, Nigeria between the 1st of January 2013 to 31st December 2022. The age distribution and the percentage contribution of breast cancer among malignancies in young women will also be determined. 

Study Design: This is a retrospective observational study.

Place and Duration of Study: Department of Anatomic Pathology and Forensic Medicine of the Jos University Teaching Hospital, Jos, Plateau State, Nigeria between the 1st of January 2013 to 31st December 2022.

Methodology:  We extracted all 703 cases of female breast cancer diagnosed histologically and registered in the hospital-based cancer registry of Jos University Teaching Hospital, Jos, Plateau State, Nigeria. The age distribution and percentage of breast cancers diagnosed in women ≤40 years was determined. The total number of cancers diagnosed within the review period, the total number of cancers in women and the total number of cancers in women ≤40 years were also extracted and used to calculate the burden of breast cancer in relation to these groups.

Results: A total of 703 breast cancers were documented within the period of review, 211 (30.0%) of which occurred in women ≤40 years. The peak of breast cancer diagnosis occurred in the 5th decade. Female breast cancers accounted for 19.5% of all malignancies diagnosed within the period of review. They accounted for 32.5% of all cancers in women and 31.9% of cancers in women ≤40 years.

Conclusion: Female breast cancer was the commonest malignancy diagnosed during the period of our review. The proportion of cases diagnosed in young women in our study is significantly higher than observations in developed western nations.

Keywords: Breast cancer, young women, Nigeria, Jos, retrospective, unveiling

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References

Sung H, Ferlay J, Siegel RH, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians. 2021;71(3):209-49.

Colditz G, Chia KS. Invasive breast carcinoma: introduction and general features. In. Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ. WHO classification of tumours of the breast. 4th ed. Lyon: IARC press. 2012;14-31.

Anders CK, Johnson R, Litton J, Phillips M, Bleyer A. Breast cancer before age 40 years. Semin Oncol. 2009;36(3):237– 49.

Paluch-Shimon S, Cardoso F, Partridge AH, Abulkhair O, Azim HA, Bianchi- Micheli G, et al. ESO-ESMO 4th International Consensus Guidelines for Breast Cancer in Young Women (Bcy4). Ann Oncol. 2020;31(6):674–96.

DOI: 10.1016/j.annonc.2020.03.284

Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11–30.

Bleyer A, Barr R, Hayes-Lattin B, Thomas D, Ellis C, Anderson B. Biology and clinical trials subgroups of the US National Cancer Institute progress review group in adolescent and young adult oncology. The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer. 2008;8(4):288–298.

Ntekim A, Nufu FT, Campbell OB. Breast cancer in young women in Ibadan, Nigeria. African health sciences. 2009;9(4):242-246.

Althuis MD, Brogan DD, Coates RJ, Daling JR, Gammon MD, Malone KE, et al. Breast cancers among very young premenopausal women (United States). Cancer Causes and Control. 2003; 14:151-160.

Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 2006, 295;(25):2492-502.

Brinton LA, Sherman ME, Carreon JD, Anderson WF. Recent Trends in Breast Cancer Among Younger Women in the United States. JNCI J Natl Cancer Inst [Internet]. 2008 Nov 19;100(22):1643–8.

Lalloo F, Varley J, Moran A, Ellis D, O’Dair L, Pharoah P, et al. BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. Eur J Cancer. 2006;42(8):1143–1150.

Haffty BG, Choi DH, Goyal S, Silber A, Ranieri K, Matloff E, et al. Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups. Ann Oncol. 2009;20(10):1653–659.

Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, et al. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst. 1999;91(11):943–949.

Freedman RA, Partridge AH. Management of Breast cancer in very young women. The Breast. 2013;22:S176-9

Korde LA, Partridge AH, Esser M, Lewis S, Simha J, Johnson RH. Breast cancer in young women: research priorities. A report of young survival coalition research think thank meeting. Journal of adolescent and young adult oncology. 2015;4(1): 34-43.

Gravena AA, Dell Agnolo CM, Lopes TC, Demitto MD, Mello WA, Borghesan DH, et al. Breast cancer in young Brazilian women: Challenge for the oncology care. Epidemiology Research International. 2014;2014.

Assi HA, Khoury KE, Dbouk H, Khalil LE, Mouhieddine TH, El Saghir NS. Epidemiology and prognosis of breast cancer in young women. Journal of thoracic disease. 2013;5(Suppl 1):S2.

Sinaga ES, Ahmad RA, Shivalli S, Hutajulu SH. Age at diagnosis predicted survival outcome of female patients with breast cancer at a tertiary hospital ainYogyakarta, Indonesia. Pan African Medical Journal. 2018;31(1).

Ganz PA, Greendale G A, Peterson L, Kahn B, Bower JE. Breast cancer in young women: reproductive and late health effects of treatment. Journal of Clinical Oncology. 2003; 21: 4184- 93.

Breast Cancer Facts & Figures 2019-2020. Accessed October 15th, 2023.

Available:https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-andfigures/ breast-cancer-facts-and-figures-2019-2020.pdf

Tichy JR, Lim E, Anders CK. Breast Cancer in Adolescents and Young Adults: A Review With a Focus on Biology. J Natl Compr Cancer Netw. 2013;11(9): 1060–9.

Johnson RH, Anders CK, Litton JK, Ruddy KJ, Blayer A. Breast cancer in adolescents and young adults. Pediatric blood and cancer. 2018;65(12):e27397.

Latif S, Perveen S, Iqbal M, Ahmed T, Bux KM, Jafri SN. Et al. Epidemiology of Carcinoma Breast in Young Adolescence Women. Cureus. 2022;14(3): e23683.

DOI:10.7759/cureus.23683

Sheereen S, Das P, Khuntia PK, Lobo FD, Patel W, Das R, et al. Breast Cancer in Young Women: Experience from a Tertiary Care Hospital of Coastal India. Int J Med Public Health. 2022;12(2):91-5.

Dite GS, Jenkins MA, Southey MC, et al. Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations. J Natl Cancer Inst. 2003;95(6):448–457.

Keegan TH, DeRouen MC, Press DJ, Kurian AW, Clarke CA. Occurrence of breast cancer subtypes in adolescent and young adult women. Breast Cancer Res. 2012; 14:1-9.

Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012;131:1061–66.

Partridge AH, Hughes ME, Ottesen RA, Wong YN, Edge SB, Theriault RL, et al. The effect of age on delay in diagnosis and stage of breast cancer. Oncologist. 2012;17(6):775–82.

Ademuyiwa FO, Cyr A, Ivanovich J, Thomas MA, Managing breast cancer in young women: Challenges and solutions. Breast cancer: targets and therapy. 2005;1-2.

Dunn J, Steginga SK. Young women’s experience of breast cancer: Defining young and identifying concerns. Psycho-Oncology. 2000;9:137-46.

Schover LR. Sexuality and body image in younger women with breast cancer. J Natl Cancer Inst Monogr. 1994;16:177-82.

Nkubli BF, Auwal A, Obi CN, Nwobi CI, Muhammed MN, Geoffrey L, et al.