Therapeutic for the Management of Pancreatic Head Adenocarcinoma about 40 Cases
Published: 2023-05-05
Page: 54-67
Issue: 2023 - Volume 6 [Issue 1]
Saad Rifki Jai
Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Kenza Benjelloun Touimi *
Department of Digestive Cancer Surgery and Liver Transplantation, CHU Ibn Rochd, Casablanca, Morocco.
Amal Hajri
Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Driss Erguibi
Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Rachid Boufettal
Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Farid Chehab
Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Pancreatic cancer accounts for the majority of malignant pancreatic lesions. Its incidence is increasing and its prognosis is poor.
Most patients are asymptomatic during the early course of disease, which often leads to delay in diagnosis.
Treatment options include surgery, chemotherapy, and palliative care.
The objective of this work is to describe and analyze the epidemiological and clinical profile and the therapeutic management of adenocarcinomas of the head of the pancreas as well as to report the experience of the digestive oncology and liver transplant department of the CHU IBN ROCHD, through a retrospective study spread over a period of 02 years, from January 2020 to December 2022.
This work is important for scientific community because pancreatic cancers had remained without symptoms for a long time, and they are diagnosed at an advanced stage.
Keywords: Pancreas, adenocarcinoma, therapeutic
How to Cite
Downloads
References
Neuzillet C, Gaujoux S, Williet N, Bachet JB, Bauguion L, Colson Durand L, et al. Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC). Dig Liver Dis. déc 2018; 50(12):1257‑71.
Lowenfels AB, Maisonneuve P. Epidemiologic and etiologic factors of pancreatic cancer. Hematol Oncol Clin North Am. Févr. 2002;16(1):1‑16.
Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Perrault J, et al. Hereditary pancreatitis and the risk of pancreatic cancer. JNCI J Natl Cancer Inst. 1997;89(6):442‑6.
Motojima K, Tomioka T, Kohara N, Tsunoda T, Kanematsu T. Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas. J Surg Oncol. 1992;49(1):58‑62.
Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94 (2):153‑6.
Midha S, Chawla S, Garg PK. Modifiable and non-modifiable risk factors for pancreatic cancer: A review. Cancer Lett. 2016;381(1):269‑77.
Yu J, Blackford AL, dal Molin M, Wolfgang CL, Goggins M. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut. 2015;64 (11):1783‑9.
Wahi MM, Shah N, Schrock CE, Rosemurgy AS, Goldin SB. Reproductive factors and risk of pancreatic cancer in women: A review of the literature. Ann Epidemiol. 2009;19(2):103‑11.
Duell EJ, Maisonneuve P, Baghurst PA, Bueno-de-Mesquita HB, Ghadirian P, Miller AB, et al. Menstrual and reproductive factors and pancreatic cancer in the SEARCH program of the IARC. Cancer Causes Control. 2009;20(9): 1757‑62.
Anand V, Bakr M, Reddy R, Wakefield D, Provost J, Bach C, et al. Comparison of the accuracy of EUS and MRCP in the diagnosis of choledocholithiasis: 1. Am J Gastroenterol. 2015;110:S1.
Arnold LD, Patel AV, Yan Y, Jacobs EJ, Thun MJ, Calle EE, et al. Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity? Cancer Epidemiol Biomarkers Prev. 2009;18(9):2397‑405.
Silverman DT, Hoover RN, Brown LM, Swanson GM, Schiffman M, Greenberg RS, et al. Why do black americans have a higher risk of pancreatic cancer than white Americans? Epidemiology. 2003;14(1): 45‑54.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, et al. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009;69(8):3681‑8.
Bright R. Cases and observations connected with disease of the pancreas and duodenum. J R Soc Med. 1833;MCT-18(P1):1‑56.
Bell ET. Carcinoma of the pancreas. I. A clinical and pathologic study of 609 necropsied cases. II. The relation of carcinoma of the pancreas to diabetes mellitus. Am J Pathol. 1957;33(3): 499‑523.
Green RC, Baggenstoss AH, Sprague RG. Diabetes mellitus in association with primary carcinoma of the pancreas. Diabetes. 1958;7(4):308‑11.
Clark CG, Mitchell PEG. Diabetes mellitus and primary carcinoma of the pancreas. BMJ. 1961;2(5262):1259‑62.
Dobbins M, Decorby K, Choi BCK. The Association between obesity and cancer risk: A meta-analysis of observational studies from 1985 to 2011. ISRN Prev Med. 2013;2013:1‑16.
Zheng W, Lee SA. Well-done meat intake, heterocyclic amine exposure, and cancer risk. Nutr Cancer. 2009;61(4):437‑46.
Fink RS, Adrian TE, Margot DH, Bloom SR. Increased plasma pancreatic polypeptide in chronic alcohol abuse. Clin Endocrinol (Oxf). 1983;18(4):417‑21.
Lieber CS, Seitz HK, Garro AJ, Worner TM. Alcohol-related diseases and carcinogenesis. Cancer Res. 1979;39(7 Pt 2):2863‑86.
Stewart S, Jones D, Day CP. Alcoholic liver disease: New insights into mechanisms and preventative strategies. Trends Mol Med. 2001;7(9):408‑13.
Agarwal D. Molecular genetic aspects of alcohol metabolism and alcoholism. Pharmacopsychiatry. 1997;30(03):79‑84.
El-Serag HB, Engels EA, Landgren O, Chiao E, Henderson L, Amaratunge HC, et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology. 2009;49(1):116‑23.
Hassan MM, Li D, El-Deeb AS, Wolff RA, Bondy ML, Davila M, et al. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol. 2008;26(28): 4557‑62.
Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin. 2017;67(1):7‑30.
Ballehaninna UK, Chamberlain RS. The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal. J Gastrointest Oncol. 2012;3(2):105‑19.
Soriano A, Castells A, Ayuso C, Ayuso JR, de Caralt MT, Ginès MÀ, et al. Preoperative staging and tumor resectability assessment of pancreatic cancer: Prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol. 2004;99(3):492‑501.
Vareedayah AA, Alkaade S, Taylor JR. Pancreatic adenocarcinoma. Mo Med. 2018;115(3):230‑5.
Shaib Y, Davila J, Naumann C, El-Serag H. The impact of curative intent surgery on the survival of pancreatic cancer patients: A U.S. population-based study. Am J Gastroenterol. 2007;102(7):1377‑82.
Fernández-del Castillo C, Morales-Oyarvide V, et al. Evolution of the whipple procedure at the Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S56-63.
Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, et al. Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2000; 4(6):567‑79.
Gouma DJ, Busch ORC, van Gulik TM. Pancreatic carcinoma: Palliative surgical and endoscopic treatment. HPB. 2006;8 (5):369‑76.