Ehrlich Solid Tumor Induced Injury and Toxicity in Liver and Kidney in Female Mice

Maha Elkholy

Zoology Department, Faculty of Science, Tanta University, Egypt.

Afaf El-Atrash

Zoology Department, Faculty of Science, Tanta University, Egypt.

Ehab Tousson *

Zoology Department, Faculty of Science, Tanta University, Egypt.

*Author to whom correspondence should be addressed.


Abstract

Background and Objective: Cancer can develop in any organ at any time; it is a cellular malignancy that causes a breakdown in normal cell-cycle regulation, leading to unchecked proliferation and a lack of differentiation. It is the main factor in human mortality. The therapeutic efficacy of currently available drugs is minimal, and they do not prevent the growth of cancer. Current work aimed to study the effect of Ehrlich solid tumor (EST) on liver and kidney in female mice.

Materials and Methods: Twenty mice were randomly and equally divided into two groups and each group consists of 10 mice; 1st group is control group in which mice did not receive any treatment and 2nd group is EST group, including mice, each mouse were injected subcutaneously with 2.5-3×106 EAC cells.

Results: Current results revealed that; EST induced significant increase in the levels of serum urea, creatinine, potassium, chloride, aspartate transaminase (AST) and alanine transaminase (ALT) activities and alkaline phosphatase (ALP), kidney and liver injuries and cconversely, a significant decrease in sodium, calcium as associated to control.

Conclusion: Current results indicated that EST induced damage and toxicity in liver and kidney.

Keywords: Ehrlich solid tumor, mice, kidney functions, liver functions


How to Cite

Elkholy, M., El-Atrash, A., & Tousson, E. (2022). Ehrlich Solid Tumor Induced Injury and Toxicity in Liver and Kidney in Female Mice. Asian Oncology Research Journal, 5(1), 113–119. Retrieved from https://journalaorj.com/index.php/AORJ/article/view/68

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References

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424.

Siegel R, Desantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoppa S, Hachey M, Kirch R, Jemal A, Ward E. Cancer treatment and survivorship statistics. CA Cancer J Clin. 2012;62(4):220-41.

Sosa V, Moline T, Somoza R, Paciucci R, Kondoh H, Me LL. Oxidative stress and cancer: An overview. Ageing Res Rev, 2013;12:367-90.

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. International Journal of Cancer. 2019; 144(8):1941-53.

Saad EA, Hassanien MM, El-Lban FW. Nickel (II) diacetyl monoxime-2-pyridyl hydrazone complex can inhibit Ehrlich solid tumor growth in mice: A potential new antitumor drug. Biochem. Biophys. Res. Commun. 2017;484:579–585.

Rodgers KM, Udesky JO, Rudel RA, Brody JG. Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. Environmental Research. 2018;160:152-82.

Elgharabawy RM, El Sayed IE, Rezk NA, Tousson E. Therapeutic impact of costus (Saussurea lappa) against Ehrlich solid tumor-induced cardiac toxicity and DNA damage in female mice. Frontiers in Pharmacology. 2021;12.

Abd Eldaim MA, Tousson E, El Sayed IE, Abd El AE, Elsharkawy HN. Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice. Biomedicine & Pharmacotherapy. 2019;115:108908.

Abd Eldaim MA, Tousson E, El Sayed IE, Abd Elmaksoud AZ, Ahmed AA. Ameliorative effects of 9-diaminoacridine derivative against Ehrlich ascites carcinoma–induced hepatorenal injury in mice. Environmental Science and Pollution Research. 2021a;28:21835–21850.

Oshiba RT, Touson E, Elsherbini YM, Abdraboh ME. Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma. BioFactors. 2021;31: 1758.

Aldubayan MA, Elgharabawy RM, Ahmed AS, Tousson E. Antineoplastic activity and curative role of avenanthramides against the growth of Ehrlich solid tumors in mice. Oxidative medicine and cellular longevity; 2019. Article ID 5162687.

Available:https://doi.org/10.1155/2019/5162687

El-Masry TA, Al-Shaalan NH, Tousson E, Buabeid M, Alyousef AM. The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis and proliferation in mice. Pak. J. Pharm. Sci. 2019;32(6):2801-2810.‏

El-Masry T, Al-Shaalan N, Tousson E, Buabeid M, Al-Ghadeer A. Potential therapy of vitamin B17 against Ehrlich solid tumor induced changes in Interferon gamma, Nuclear factor kappa B, DNA fragmentation, p53, Bcl2, survivin, VEGF and TNF-α Expressions in mice. Pak. J. Pharm. Sci. 2020;33(1):393-401.

Mutar TF, Tousson E, Hafez E, Abo Gazia M,Salem SB. Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice. Environmental Toxicology. 2020; 35(4):528-537.‏

Alotaibi B, Tousson E, El‐Masry TA, Altwaijry N, Saleh A. Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice. Environmental Toxicology. 2021;36(1):105-13.

Tousson E, Bayomy MF, Ahmed AA. Rosemary extract modulates fertility potential, DNA fragmentation, injury, KI67 and P53 alterations induced by etoposide in rat testes. Biomedicine & Pharmacotherapy. 2018;98:769-74.

Tousson E, Hafez E, Zaki S, Gad A. P53, Bcl-2 and CD68 expression in response to amethopterin-induced lung injury and ameliorating role of l-carnitine. Biomedicine & Pharmacotherapy. 2014; 68(5):631-9.

Moustafa AH, Ali EM, Moselhey SS, Tousson E, El-Said KS. Effect of coriander on thioacetamide-induced hepatotoxicity in rats. Toxicology and Industrial Health. 2014;30(7):621-9.

El-Moghazy M, Zedan NS, El-Atrsh AM, El-Gogary M, Tousson E. The possible effect of diets containing fish oil (omega-3) on hematological, biochemical and histopathogical alterations of rabbit liver and kidney. Biomedicine & Preventive Nutrition. 2014;4(3):371-7.

Tousson E, El‐Atrsh A, Mansour M, Abdallah A. Modulatory effects of Saussurea lappa root aqueous extract against ethephon‐induced kidney toxicity in male rats. Environmental Toxicology.‏ 2019;34(12):1277-1284.

Patton CJ, Crouch SR. Spectrophoto-metric and kinetics investigation of the berthelot reaction for the determination of ammonia. Analytical chemistry. 1977; 49(3):464-9.

Tousson E. Histopathological alterations after a growth promoter boldenone injection in rabbits. Toxicology and Industrial Health. 2016;32(2):299-305.

DeSantis C, Ma J, Bryan L, Jemal A. 'Breast cancer statistics, 2013'. CA: A Cancer Journal for Clinicians. 2014;64(1): 52-62.

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: A Cancer Journal for Clinicians. 2011;61(2):69-90.

Ibrahim HM, Ghaffar FRA, El-Elaimy IA, Gouida MS, Antitumor and immune-modulatory efficacy of dual-treatment based on levamisole and/or taurine in Ehrlich ascites carcinoma-bearing mice. Biomedicine & Pharmacotherapy. 2018;106:43-49.

Said UZ, Ahmed NH, Medhat AM, Mustafa MM, Effects of omega-3 fatty acids against Ehrlich carcinoma-induced hepatic dysfunction. Journal of Cancer Research and Experimental Oncology. 2014;6(2):20-28.

Abd Eldaim MA, Tousson E, Soliman MM, El Sayed IE, Aleem AA, Elsharkawy HN. Grape seed extract ameliorated Ehrlich solid tumor-induced hepatic tissue and DNA damage with reduction of PCNA and P53 protein expression in mice. Environmental Science and Pollution Research. 2021b;28(17):21835-50.

Tousson E, Hafez E, Gazia MM, Salem SB, Mutar TF. Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma–induced liver toxicity. Environmental Science and Pollution Research. 2020;27:9236–9246.