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The general frequency and mortality consisting of Oral Squamous Cell Carcinoma (OSCC) is very high and the overall number of oral cancers has been consistently increasing in the world. Oral Squamous Cell Carcinoma (OSCC) is the most typical variety of oral cancer; it causes damage to oral epithelial cells due to accumulation consisting of multiple genetic changes in the cells. OSCC continues to be major cause of mortality in sufferers along with head and neck cancers. Alcohol, smoking and tobacco chewing alone or as well as smokeless tobacco and betel quid are potential carcinogens which contribute to the far natural event of OSCC. The current review focuses on apoptosis induction in human Oral Squamous Cell Carcinoma (OSCC) cells. Several natural products, chemotherapeutic drugs metabolic inhibitors, gene manipulations and hormone receptor ligands cause the general programmed cell death immediately or not directly via relapsing the anti-apoptotic pathways. The main focus of this review is on Apoptotic activities caused by Natural compounds in OSCC which provide us a chemoprevention against cancer.
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