Asian Oncology Research Journal

Background and Objective: Cisplatin (CP), a potent antineoplastic drug and its anti-cytotoxic activity is used to treat many cancer types. The present study aimed to examine the possible modifying effects of ginseng extract against spleen oxidative stress and injury induced by Cisplatin in rats.

Materials and Methods: A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and ginseng groups respectively while the 3^rd group was Cisplatin rat group; the 4^th and 5^th groups were Co- and post treated Cisplatin rat with ginseng respectively and the 6^th group was Cisplatin self-healing rat group.

Results: Spleen malondialdehyde (MDA) levels in Cisplatin group showed a significant increase when compared with control group, in contrast, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and total protein levels were a significant decrease. Treatment of Cisplatin with ginseng improved spleen toxicity induced by Cisplatin. Ginseng possessed various protective mechanisms against Cisplatin induced spleen toxicity throughout co- and post- treatment.

Conclusion: We can conclude that Co-treatment with ginseng has beneficial properties and can reduce the spleen oxidative stress and tissue injury induced by Cisplatin.