Therapeutic Impact of Etoposide against Ehrlich Solid Tumor Induced Improvement in Electrolytes, Liver and Kidney Toxicity in Female Mice
Ibrahim El Tantawy El Sayed
Department of Chemistry, Faculty of Science, Menoufia University, Egypt.
Ehab Tousson
Department of Zoology, Faculty of Science, Tanta University, Egypt.
Manar Atia Sakr
Department of Chemistry, Faculty of Science, Menoufia University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background and Objective: Breast cancer is the most common type of cancer among women and the second most frequent kind of tumor worldwide. This study aims to find the renal and hepatic protective effect of etoposide against Ehrlich solid tumor induced liver and kidney toxicity in female.
Materials and Methods: A total of 60 albino females’ mice were separated into four groups (1st, control group; 2nd, Etoposide group; 3rd, EST group; 4th, EST treated with Etoposide group). EST group divulge changes in liver, kidney function and Electrolytes under study compared with control group.
Results: Our results revealed that; serum urea, creatinine, potassium ions (K+), chloride ions(Cl-), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) have a significant increase in EST group compared with control group. In contrast, serum sodium ions (Na+), calcium ions (Ca++), total protein and albumen have a significant decrease in EST group compared with control group. On the other hand, treatment with Etoposide for 14 days improved these changes in liver and kidney functions.
Conclusion: The present study confirmed that Etoposide has therapeutic role against liver and kidney toxicity induced by Ehrlich solid tumor. Further studies are warranted to explore its mode of action and safety for medicinal use in liver and kidney therapy during cancer treatments.
Keywords: Ehrlich solid tumor, etoposide, mice, liver and kidney functions