Asian Oncology Research Journal <p style="text-align: justify;"><strong>Asian Oncology Research Journal</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AORJ/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cancer, Tumor&nbsp;and&nbsp;Oncology&nbsp;research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;"><img src="/public/site/images/sciencedomain/free-sign.gif" width="80" height="32"></p> <p style="text-align: justify;"><strong>Publication Charge: FREE</strong>. All the manuscripts submitted within this month will be published free of cost. There is no publication charge for this month.&nbsp;</p> en-US (Asian Oncology Research Journal) (Asian Oncology Research Journal) Sat, 12 Oct 2019 00:00:00 +0000 OJS 60 Antineoplastic Activities of Grape Seed Proanthocyanidin Extract against Ehrlich Solid Tumor Bearing Mice Induced Alterations in AFP, CEA, TNF-α and DNA Damage <p><strong>Background and Objective:</strong> Cancer is initiated due to abnormalities in the DNA of the affected cells leading to an extra mass of tissue termed a tumor. Breast cancer is the most public cancer amongst women world-wide. The present work is designed to investigate the ameliorating potential effects of grape seed proanthocyanidin extract (GSPE) in inhibition of Ehrlich cells growth and tumor development as a model for breast cancer. Also; the present work is designed to investigate the effect of GSPE on the changes in the levels of AFP, CEA, TNF-α and hematological alterations, and DNA damage examination on Ehrilch solid tumor (EST) bearing mice.</p> <p><strong>Materials and Methods</strong><strong>:</strong> A total of 40 female mice were evenly distributed amongst four groups (G1, control group; G2, GSPE group; G3, EST group; IV, EST+GSPE group).</p> <p><strong>Results:</strong> Results revealed increased incidences of tumor growth in the untreated EST group, along with elevated levels of serum AFP, CEA, TNF-α, WBCs, platelets and DNA damage and an associated reduction in RBCs and Hb%. Treatment of EST with GSPE (EST+GSPE) modulates and improved these changes in CBC, tumor markers and DNA damage as compared to mice bearing EST.</p> <p><strong>Conclusion:</strong> This finding calls for more investigation on the benefits of grape seed proanthocyanidin extract (GSPE) as antineoplastic activity on other tumors as Ehrlich ascites carcinoma or cancer.</p> Massoud Ahmed, Tousson Ehab, Said Noor Eldin Ahmed, Elwan M. Mona, Hameed M. Haneen ##submission.copyrightStatement## Fri, 12 Oct 2018 00:00:00 +0000 Ameliorative Effects of Spirulina and Chamomile Aqueous Extract against Mice Bearing Ehrlich Solid Tumor Induced Apoptosis <p><strong>Aims: </strong>Cancer is caused by an imbalance in the rate of proliferation and apoptosis and the positive effect of anticancer therapy is taken into consideration when its ability to initiate apoptosis in cancer cells<strong>.</strong> In vivo; several experimental models established in experimental animals besides the Ehrlich solid tumor (EST), derived from the mouse breast adenocarcinoma. This study aims to determine the curative role of spirulina or/ and chamomile to acting effectively in &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;inhibition of Ehrlich cells growth and tumor development, in addition to the therapeutic activity of spirulina and chamomile aqueous extract on Ehrlich tumor in the solid forms induced apoptosis in solid tumor.</p> <p><strong>Study Design:</strong>&nbsp; A total of 80 mice were equally divided into eight groups (Group 1, Control group; Group 2, spirulina group; Group 3, Chamomile group; Group 4, spirulina and chamomile group; Group 5, Ehrlish solid tumor group; Group 6: Mice Ehrlish solid tumor treated orally with spirulina; Group 7, Mice Ehrlish solid tumor treated orally with chamomile; Group 8, Mice Ehrlish solid tumor treated orally with both spirulina and chamomile for 2 weeks).</p> <p><strong>Results:</strong> In the current study; a significant decrease in tumour volume, an decrease in apoptotic P53, Bax and pro apoptotic Caspase 3 expressions and increased in Bcl2 expressions was detected after the treatment of EST with extract of chamomile and spirulina together and spirulina extract only as compared with the tumour volume of EST group. In conclusion, the present study demonstrated that the combination of spirulina and chamomile has a better effect than each of spirulina or chamomile alone against Ehrlich solid tumor in mice.</p> <p><strong>Conclusion:</strong> Ehrlich solid tumor induced apoptosis by increased P53, Bax, Caspase 3 and decrease Bcl2; treatment of Ehrlich solid tumor with combination of spirulina and chamomile improved these alterations in apoptosis markers.</p> Afaf El-Atrsh, Ehab Tousson, Eman E. Elnahas, Ahmed Massoud, Marwan Al-Zubaidi ##submission.copyrightStatement## Fri, 25 Oct 2019 00:00:00 +0000 Use of DNA Methylation in Cancer Therapy <p>The aim of this paper is the review the factors that determine cancer progression which would help in the treatment and diagnosis of the disease. Cancer is a leading life-threatening disease and despite the recent technological advancement, there is still a poor survival rate in cancer patients because of inadequate diagnosis and poor prognosis of cancer.</p> Ayoola Abimbola, Christian Bach ##submission.copyrightStatement## Fri, 25 Oct 2019 00:00:00 +0000