Asian Oncology Research Journal <p style="text-align: justify;"><strong>Asian Oncology Research Journal</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AORJ/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cancer, Tumor&nbsp;and&nbsp;Oncology&nbsp;research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;"><img src="/public/site/images/sciencedomain/free-sign.gif" width="80" height="32"></p> <p style="text-align: justify;"><strong>Publication Charge: FREE</strong>. All the manuscripts submitted within this month will be published free of cost. There is no publication charge for this month.&nbsp;</p> Asian Oncology Research Journal en-US Asian Oncology Research Journal Langerhans Cell Histiocytosis: Clinical, Histopathological and Radiological Case Series Study: An Institutional Experience <p><strong>Background:</strong> Langerhans cells histiocytosis (LCH) is a rare disease characterized by the uncontrolled proliferation of Langerhans cells (LCs). This study aimed to explore the clinic-epidemiological and pathological data of that disease in our population.</p> <p><strong>Methods:</strong> Sixteen patients were referred to the Dermatology and the Clinical Oncology &amp; Nuclear Medicine Departments of our university during the 6 years from 2007 to 2012. Records data were retrospectively analyzed. Pathologic specimens and radiologic films were reassessed by consultants.</p> <p><strong>Results:</strong> Pediatric age and male sex predominated. The multifocal uni system (MUS) was the commonest presentation (50% of cases) while the multifocal multisystem (MMS) was found in 37.5% of cases including a case of Letterer-Siwe disease. Microscopic examination revealed dense infiltrate mainly of LCs with characteristic features and positive immunostaining for S100, CD1a and CD68. The treatment was heterogeneous. The follow-up time was well documented for 12 cases (mean=5 years). The prognosis was variable. Limitation of this study was the retrospective nature.</p> <p><strong>Conclusions:</strong> This case series showed the predominance of males, pediatric age, bone involvement and good treatment response. Diversity of system involvement necessitates a multidisciplinary approach. This diversity also could be a cause of underdiagnosis.</p> Maha El-Gayyar Manar Sallam Mohamed Khaled Mohamed El-Mougy Amany El-Hawwary Amal Halim Hala El. Shenshawy Adel El-Badrawy ##submission.copyrightStatement## 2020-01-22 2020-01-22 6 19 IL-6 Blockade Limitations as an Anticancer Strategy: Literature Review and Proposal of Explanations for Unexpected Results <p>IL-6 is a cytokine with multiple protumorigenic effects, making it an interesting therapeutic target. IL-6 inhibitors with an acceptable safety profile had been developed and tested in experimental and clinical trials. However, the outcomes were not as expected theoretically. Possible explanations of this discordance had been advocated by authors and will be reviewed in this paper. Additional reasons, such as the antitumoral effects of IL-6 and overcompensation&nbsp;by alternative&nbsp;agents&nbsp;will be proposed. These may also explain the trending to negative results constated in some clinical trials.&nbsp;</p> Mohamed Islam Delma ##submission.copyrightStatement## 2020-01-10 2020-01-10 1 5