Asian Oncology Research Journal 2019-01-03T09:47:51+00:00 Asian Oncology Research Journal Open Journal Systems <p style="text-align: justify;"><strong>Asian Oncology Research Journal</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AORJ/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cancer, Tumor&nbsp;and&nbsp;Oncology&nbsp;research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;"><img src="/public/site/images/sciencedomain/free-sign.gif" width="80" height="32"></p> <p style="text-align: justify;"><strong>Publication Charge: FREE</strong>. All the manuscripts submitted within this month will be published free of cost. There is no publication charge for this month.&nbsp;</p> Determination of the Location of Uracil-DNA Glycosylase (UDG) Protein in Lungs Cancer Cells 2019-01-03T09:29:47+00:00 A. A. Minjibir M. Ali <p><strong>Background:</strong>&nbsp;In every 24 hours, about 100-500 Cytosines undergo unprepared deamination in a particular cell. The deamination of cytosine to uracil is one of the major pro-mutagenic events in DNA causing G: C→A: T transitional mutations if not repaired before replication take place. Uracil-DNA Glycosylase (UDG) is one of the major proteins that coordinate multiple cellular activities in the cell. However, its positions in the cell determine the type of activity it controls. Repair of uracil-DNA is achieved in base-excision pathway initiated by UDG.&nbsp;</p> <p><strong>Aim:</strong>&nbsp;The research was aimed to determine the location of&nbsp;<em>UDG&nbsp;</em>in lungs cancer (SW480) cells.</p> <p><strong>Methodology:</strong>&nbsp;To determine the location of&nbsp;<em>UDG&nbsp;</em>protein in lungs cancer SW480 cells, the cells were treated with 100 mU Bleomycin (BLM) and 100ug 5-Flourourecil (5-FU).</p> <p><strong>Results:</strong>&nbsp;The FITES florescence photograph of the cells shows that UDG protein is localizing in the cytoplasm as seen by a glowing green colour of the tagged antibody around the cell’s nucleus in the cytoplasm in both treated and untreated cells.</p> <p><strong>Conclusion:&nbsp;</strong>The DAPI florescence photograph shows a dark central image with no glowing of anti-mouse antibody indicating the absence of the protein in the nucleus.</p> 2018-01-29T00:00:00+00:00 ##submission.copyrightStatement## Primary Mucosal Melanoma of Upper Alveolar Ridge and Hard Palate – A Case Report 2019-01-03T09:36:54+00:00 F. Massilamani S. Kailasam C. K. Vishnu Priya R. Poorani <p>Melanoma is a potentially aggressive malignant tumor that arises from melanocytes and is most commonly cutaneous in origin. Patients greater than 60 years of age have a higher incidence of malignant melanoma with a slight male predilection. Primary oral melanoma is an extremely rare malignant tumor. The predominant site of primary oral melanoma is the hard palate and maxillary alveolus. The asymptomatic early stage of the lesion makes the late diagnosis of the tumor. This article presents a rare case of malignant melanoma of maxilla with an asymptomatic palatal pigmentation.</p> 2018-02-12T00:00:00+00:00 ##submission.copyrightStatement## Infantile Haemangioma in a ‘Beard’ Distribution: A Case Report 2019-01-03T09:47:51+00:00 Iragbogie Al-Mustapha Imoudu Maimuna Orahachi Yusuf Hayatu Ahmad <p><strong>Aim:</strong>&nbsp;To highlight infantile haemangioma as a possible cause of upper airway obstruction in young infants presenting with stridor particularly when there are associated cutaneous lesions.</p> <p><strong>Presentation of Case:</strong>&nbsp;We report a 10 week-old baby girl admitted into the emergency paediatric unit of the Federal Medical Centre Azare, Nigeria with a 3-week history of a skin lesion initially noticed as a flat discoloured area over the sternal region. It progressively spread to involve the anterior aspect of the neck and chin and became associated with progressive difficulty with breathing. Examination findings revealed a restless, acutely ill child with inspiratory stridor. She had purplish plaques in the areas mentioned above as well as the lower lip and ventral aspect of the tongue. She improved remarkably following intranasal oxygen, intravenous dexamethasone and oral propranolol administration and was discharged after 4 days of admission on oral prednisolone and propranolol.</p> <p><strong>Discussion:</strong>&nbsp;Infantile haemangiomas are benign vascular neoplasms that have a characteristic clinical course marked by early proliferation and followed by spontaneous involution. Infrequently, infantile haemangiomas may impinge on vital structures provoking certain related symptoms. Airway obstruction is an uncommon complication and may be particularly challenging for young infants who are obligate nose breathers. Subglottic haemangiomas are also uncommon compared to the cutaneous forms and may be life threatening with attendant airway obstruction. This was the foremost concern in our patient. Nevertheless, she responded to dexamethasone and propranolol.</p> <p><strong>Conclusion:</strong>&nbsp;It is essential to recognize the association of infantile haemangiomas presenting in a beard distribution with airway obstruction and promptly institute management of respiratory complications.</p> 2018-03-08T00:00:00+00:00 ##submission.copyrightStatement## Photodynamic Therapy for Classic (Idiopathic) Type of Kaposi's Sarcoma (Case Report) 2019-01-03T09:46:13+00:00 D. A. Tzerkovsky <p>The author report a case of a patient with classic (idiopathic) type of Kaposi's sarcoma the third toe of the foot treated successfully with&nbsp;photodynamic therapy. Photosensitizer «Photolon» (RUE «Belmedpreparaty», Republic of Belarus) was injected intravenously at a dose of 2 mg/kg body weight. Photoirradiation was carried out 3 hour after the injection of photosensitizer with the use of a semiconductor laser «UPL PDT laser» («Lemt», Republic Belarus, λ=660±5 nm) with exposure dose of 100 J/cm<sup>2</sup>&nbsp;and power density of 0.38 W/cm<sup>2</sup>. The effectiveness of treatment was assessed based on an analysis of clinical data. During the follow-up period of 3 and 6 months, no clinical signs of local recurrence in the photoirradiation area were detected.</p> 2018-04-13T00:00:00+00:00 ##submission.copyrightStatement##